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BChE/p38-α MAPK-IN-2

CAT: 0804-HY-178433Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178433Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BChE/p38-α MAPK-IN-2 is a BChE and p38-α MAPK dual inhibitor. BChE/p38-α MAPK-IN-2 inhibits hBChE with an IC50 of 5.1 nM, showing 1000-fold selectivity over hAChE. BChE/p38-α MAPK-IN-2 inhibits p38α MAPK with an IC50 of 8.12 μM. BChE/p38-α MAPK-IN-2 exhibits neuroprotective effect and can be used for the research of neurological disease, such as Alzheimer’s disease[1].
UNSPSC
12352005
Target
Cholinesterase (ChE) ; p38 MAPK
Related Pathways
MAPK/ERK Pathway; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC(NCC(NCC1=CC=CC(N2N=C(C=C2OC(N(CC3=CC=CC=C3)C)=O)C(C)(C)C)=C1)=O)=O
Molecular Formula
C27H33N5O4
Molecular Weight
491.58
References & Citations
[1]Benetik SF, et al. Transforming ureas into carbamates: From allosteric p38α MAPK ligands to dual BChE/p38α MAPK inhibitors. Bioorg Chem. 2025 Oct;165:108998.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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