P38-α MAPK-IN-9

CAT: 0804-HY-171254Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-171254Size:1 Each

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Description

P38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor (Ki: 0.057 nM). p38-α MAPK-IN-9 inhibits LPS induced TNFα production in hPBMCs (IC50: 18 nM).

CAS Number

868272-50-8

UNSPSC

12352005

Target

P38 MAPK

Related Pathways

MAPK/ERK Pathway

Field of Research

Inflammation/Immunology

Smiles

N#CC1=C(NC(C)C)N=C(N)N=C1NC2=CC(C(NC3=NOC=C3)=O)=CC=C2C

Molecular Formula

C19H20N8O2

Molecular Weight

392.41

References & Citations

[1]Liu C, et al. 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. J Med Chem. 2005 Oct 6;48 (20) :6261-70.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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P38-α MAPK-IN-9

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