P38-α MAPK-IN-9

• Description:

  P38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor (Ki: 0.057 nM) . p38-α MAPK-IN-9 inhibits LPS (HY-D1056) induced TNFα production in hPBMCs (IC50: 18 nM) [1].

• UNSPSC:

  12352005

• Target:

  P38 MAPK

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Inflammation/Immunology

• Smiles:

  N#CC1=C (NC (C) C) N=C (N) N=C1NC2=CC (C (NC3=NOC=C3) =O) =CC=C2C

• Molecular Formula:

  C19H20N8O2

• Molecular Weight:

  392.41

• References & Citations:

  [1]Liu C, et al. 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. J Med Chem. 2005 Oct 6;48 (20) :6261-70.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  868272-50-8