p38-α MAPK-IN-5

p38-α MAPK-IN-5

• CAS Number: 1443242-46-3
• UNSPSC Description: p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].
• Target Antigen: p38 MAPK
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/p38-α-mapk-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@H]1CC[C@H](C2=C1C=CC=C2)OC(C=C3)=CN4C3=NN=C4N5[C@H](CCCC5)C)NC6=CC(C(C)(C)C)=NN6C7=CN(N=C7)CCN(C)C
• Molecular Weight: 679.86
• References & Citations: [1]Elisabetta Armani, et al. Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases. J Med Chem. 2022 May 26;65(10):7170-7192.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported