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GPX4-IN-20

CAT: 0804-HY-178389Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178389Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GPX4-IN-20, a Arctigenin derived, is a GPX4& molecular gluedegrader. GPX4-IN-20 induces ferroptosis by increasing lipid ROS levels and suppressing GSH levels. GPX4-IN-20 reduces the protein expression and enzyme activity of GPX4 in a dose-dependent manner without affecting other ferroptosis-related proteins. GPX4-IN-20 induces ubiquitination-dependent proteasomal degradation of GPX4. GPX4-IN-20 also increases the level of malondialdehyde (MDA) in HCT-116 cells. GPX4-IN-20 can be used for the research of colorectal cancer[1].
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase; Molecular Glues; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClCC(NC(C=C1)=CC=C1C(OC(C(OC)=C2)=CC=C2C[C@@H](C(OC3)=O)[C@H]3CC4=CC(OC)=C(OC)C=C4)=O)=O
Molecular Formula
C30H30ClNO8
Molecular Weight
568.01
References & Citations
[1]Wang YX, et al. Design, synthesis, and biological evaluation of arctigenin derivatives as novel GPX4 inhibitors in colorectal cancer cells. Eur J Med Chem. 2025;300:118181.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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