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GPX4-IN-20

CAT: 0013-GTR19275820-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275820-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GPX4-IN-20 is a derivative of Arctigenin and acts as a molecular glue degrader of GPX4, inducing ferroptosis by increasing lipid ROS levels and inhibiting GSH levels. It reduces the protein expression and enzyme activity of GPX4 in a dose-dependent manner without affecting other ferroptosis-related proteins. GPX4-IN-20 promotes ubiquitin-dependent proteasomal degradation of GPX4 and elevates malondialdehyde (MDA) levels in HCT-116 cells. This compound is applicable in colorectal cancer research.
Storage Conditions
-20°C
Notes
For research use only.

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