DGKα&ζ-IN-2

CAT: 0804-HY-178327Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178327Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DGKα/ζ-IN-2 is a potent, orally active and selective dual DGKα/ζ inhibitor with IC50 values of 23 nM (DGKα) and 1.2 nM (DGKζ) . DGKα/ζ-IN-2 exhibits selectivity over other DGK isoforms, such as DGKβ and DGKγ. DGKα/ζ-IN-2 shows robust and dose-dependent immune activation in the presence of antigen presentation in an OT-1 murine model. DGKα/ζ-IN-2 can be used for antitumor immunity[1].
CAS Number
[3039488-61-1]
UNSPSC
12352005
Target
DGK; Interleukin Related
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
F/C(C1=NC(C2=CC=NN=C2)=CN=C1)=C\C3=CC=C(C(C(F)(F)F)=C3N4CCOC5(C4)CCN(CC5)CC6CC6)OC7=CC=CC=C7
Molecular Formula
C35H34F4N6O2
Molecular Weight
646.68
References & Citations
[1]Xiang M, et al. Discovery of Fluoroalkenes as Dual Inhibitors of Diacylglycerol Kinases Alpha and Zeta (DGKα/ζ) . J Med Chem. 2025 Oct 9;68 (19) :20789-20813.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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