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DGKα&ζ-IN-2

CAT: 0013-GTR19273868-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273868-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DGKα/ζ-IN-2 is a potent, orally active, and highly selective inhibitor of DGKα/ζ, exhibiting IC50 values of 23 nM for DGKα and 1.2 nM for DGKζ. It shows excellent selectivity over other DGK isoforms such as DGKβ and DGKγ. In the OT-1 mouse model, DGKα/ζ-IN-2 demonstrates significant and dose-dependent immune activation under antigen-presenting conditions. This compound can be utilized in research related to anti-tumor immunity.
CAS Number
3039488-61-1
Smiles
C (F) (F) (F) C1=C (C (/C=C (\F) /C2=NC (=CN=C2) C=3C=CN=NC3) =CC=C1OC4=CC=CC=C4) N5CC6 (CCN (CC7CC7) CC6) OCC5
Molecular Formula
C35H34F4N6O2
Molecular Weight
646.69
Storage Conditions
-20°C
Notes
For research use only.

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