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DGKα-IN-10

CAT: 0804-HY-178062Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178062Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DGKα-IN-10 is an orally active and potent DGKα inhibitor with an IC50 of 0.27 nM. DGKα-IN-10 can induce IL-2 release and T cells proliferation. DGKα-IN-10 can be used for the research of cancer, such as colon cancer[1].
CAS Number
2980579-79-9
UNSPSC
12352005
Target
DGK; Interleukin Related
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
N#CC1=NC2=C(N(C)C(C=C2N3CCC(C4=NC5=CC(C)=CC=C5O4)CC3)=O)C=C1OCCO
Molecular Formula
C25H25N5O4
Molecular Weight
459.50
References & Citations
[1]Lu H, et al. Discovery of Novel, Potent, Selective, and Orally Available DGKα Inhibitors for the Treatment of Tumors. J Med Chem. 2025 Sep 25;68 (18) :19645-19660.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-2

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