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HDAC1-IN-11

CAT: 0804-HY-178021Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178021Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC1-IN-11 (Compound 6) is a HDAC1 inhibitor with an IC50 of 106.6 nM. HDAC1-IN-11 inhibits the expression of Sp1 and RAD51, thereby inducing Caspase-dependent apoptosis. HDAC1-IN-11 has antitumor activity and sensitizes Etoposide and Gemcitabine (HY-17026), promoting synergistic death of NSCLC cells through the inhibition of homologous recombination and non-homologous end joining (NHEJ) pathways involved in DNA DSB repair. HDAC1-IN-11 can be used for chemotherapy of cancers like NSCLC research[1].
UNSPSC
12352005
Target
Apoptosis; Caspase; DNA/RNA Synthesis; HDAC; RAD51
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
NC1=CC=CC=C1NC(C2=CC=C(C=C2)CN3C(N(C(C4=CC=CC=C43)=O)CCC5=CC=CC=C5)=O)=O
Molecular Formula
C30H26N4O3
Molecular Weight
490.55
References & Citations
[1]Huang HC, et al. Establishing a noncanonical zinc-binding group as a selective histone deacetylase inhibitor and possible novel anticancer agent. Bioorg Chem. 2025 Aug 27;165:108917.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7; Caspase 9; HDAC1; HDAC6

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