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HDAC1-IN-5

CAT: 0804-HY-151153Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151153Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC1-IN-5 is a potent HDAC1 inhibitor with IC50 values of 15 nM and 20 nM for HDAC1 and HDAC6, respectively. HDAC1-IN-5 can enhance the acetylation of histone H3 and α-tubulin, as well as promote the activation of caspase 3 in cancer cells, thereby inducing apoptosis. HDAC1-IN-5 induces chromatin damage by binding with DNA. HDAC1-IN-5 has strong inhibitory activity against tumor growth in xenograft mice[1].
UNSPSC
12352005
Target
Apoptosis; Caspase; HDAC; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac1-in-5.html
Solubility
10 mM in DMSO
Smiles
ONC(CCCCCC1=CC=CC(C2=NN=C(C3=CC=CC=C3)S2)=C1)=O
Molecular Formula
C20H21N3O2S
Molecular Weight
367.46
References & Citations
[1]Chen C, et al. Discovery of 2,5-diphenyl-1,3,4-thiadiazole derivatives as HDAC inhibitors with DNA binding affinity. Eur J Med Chem. 2022 Jul 31;241:114634.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6

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