HDAC1-IN-3

HDAC1-IN-3

• CAS Number: 2482998-35-4
• UNSPSC Description: HDAC1-IN-3 is a potent Pf HDAC1 inhibitor. HDAC1-IN-3 shows antimalarial activity in wild-type and multidrug-resistant parasite strains. HDAC1-IN-3 shows a significant in vivo killing effect against all life cycles of parasites[1].
• Target Antigen: HDAC; Parasite
• Type: Reference compound
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage;Epigenetics
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/hdac1-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CN=C(N(CC2)CC32CN(CC4=CN(C)C5=C4C=CC(C#N)=C5)C3)N=C1)NO.[H]Cl
• Molecular Weight: 453.92
• References & Citations: [1]Wang M, et al. Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety. J Med Chem. 2022; 65(5):4156-4181.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported