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HDAC1-IN-3

CAT: 0804-HY-144297Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144297Size:1 Each
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Description
HDAC1-IN-3 is a potent Pf HDAC1 inhibitor. HDAC1-IN-3 shows antimalarial activity in wild-type and multidrug-resistant parasite strains. HDAC1-IN-3 shows a significant in vivo killing effect against all life cycles of parasites[1].
CAS Number
2482998-35-4
UNSPSC
12352005
Target
HDAC; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hdac1-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN=C(N(CC2)CC32CN(CC4=CN(C)C5=C4C=CC(C#N)=C5)C3)N=C1)NO.[H]Cl
Molecular Formula
C22H24ClN7O2
Molecular Weight
453.92
References & Citations
[1]Wang M, et al. Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety. J Med Chem. 2022; 65 (5) :4156-4181.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6; HDAC8; Plasmodium

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