Anticancer agent 273

CAT: 0804-HY-172784Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172784Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Anticancer agent 273 (Compound 9q) is a potent anticancer agent found in matrine. Anticancer agent 273 inhibits the proliferation of cancer cells (e.g., HeLa cells with an IC50 value of 4.48 μM) . Anticancer agent 273 exerts anticancer effects by modulating the expression of PI3K/AKT and activating transcription factor 4 (ATF4), which promotes endoplasmic reticulum stress and induces apoptosis. Anticancer agent 273 is promising for research of cancers, such as cervical cancer[1].
UNSPSC
12352005
Target
Akt; Apoptosis; PI3K
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
[H][C@@]12CCCN3CCC[C@@]([C@@]31[H])([C@]4(CC/C(C(N4C2)=O)=C\OC(C5=CN(C6=C5C=CC=C6)CC7=CC=CC=C7C#N)=O)[H])[H]
Molecular Formula
C33H34N4O3
Molecular Weight
534.65
References & Citations
[1]Wang X, et al. Design, synthesis and in vitro and in vivo biological evaluation of matrine derivatives as efficient anticancer agents with the characteristics of endoplasmic reticulum stress induction and apoptosis activation. Bioorg Chem. 2025 Apr 16;160:108482.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-173238Antibacterial agent 273
HY-154800Anticancer agent 113
HY-158407Anticancer agent 220
HY-149214Anticancer agent 100
HY-149062Anticancer agent 102
HY-155964Anticancer agent 153
HY-151588Anticancer agent 90
HY-160871Anticancer agent 208
HY-123715Anticancer agent 255
HY-147906Anticancer agent 71

Alternative Products

CatalogName
MBS5785535-01Anticancer agent 7
MBS5824734Anticancer agent 162
MBS5824727Anticancer agent 86
MBS5824728Anticancer agent 33
MBS5824723Anticancer agent 96
MBS5800254Anticancer agent 11
MBS5803044Anticancer agent 38
MBS5820865Anticancer agent 121
MBS5821127Anticancer agent 135
MBS5821307Anticancer agent 153

Popular Products