Anticancer agent 273

• Description:

  Anticancer agent 273 (Compound 9q) is a potent anticancer agent found in matrine. Anticancer agent 273 inhibits the proliferation of cancer cells (e.g., HeLa cells with an IC50 value of 4.48 μM) . Anticancer agent 273 exerts anticancer effects by modulating the expression of PI3K/AKT and activating transcription factor 4 (ATF4), which promotes endoplasmic reticulum stress and induces apoptosis. Anticancer agent 273 is promising for research of cancers, such as cervical cancer[1].

• UNSPSC:

  12352005

• Target:

  Akt; Apoptosis; PI3K

• Related Pathways:

  Apoptosis; PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Smiles:

  [H][C@@]12CCCN3CCC[C@@]([C@@]31[H])([C@]4(CC/C(C(N4C2)=O)=C\OC(C5=CN(C6=C5C=CC=C6)CC7=CC=CC=C7C#N)=O)[H])[H]

• Molecular Formula:

  C33H34N4O3

• Molecular Weight:

  534.65

• References & Citations:

  [1]Wang X, et al. Design, synthesis and in vitro and in vivo biological evaluation of matrine derivatives as efficient anticancer agents with the characteristics of endoplasmic reticulum stress induction and apoptosis activation. Bioorg Chem. 2025 Apr 16;160:108482.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported