BB-1701

CAT: 0804-HY-177414Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-177414Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BB-1701 is an anti-HER2 antibody-drug conjugate (ADC) . BB-1701 is composed of a humanized anti-HER2 antibody (Trastuzumab) (HY-P9907), a linker (Mal-PEG2-VCP), a microtubule inhibitor (Eribulin) (HY-13442), and the drug-linker conjugate for ADC is Mal-PEG2-VCP-Eribulin (HY-128870) . BB-1701 has a potent cytotoxicity and bystander effects on tumors with heterogeneous target expression. BB-1701 significantly induces immunogenic cell death and the activation of the immune[1].
UNSPSC
12352211
Target
Antibody-Drug Conjugates (ADCs) ; EGFR
Related Pathways
Antibody-drug Conjugate/ADC Related; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
[BB-1701]
References & Citations
[1]Wang Y, et al. Preclinical studies of BB-1701, a HER2-targeting eribulin-containing ADC with potent bystander effect and ICD activity. Antib Ther. 2024 Jun 25;7 (3) :221-232.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
ErbB2/HER2

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