CD33 splicing modulator 1 (hydrochloride)

CD33 splicing modulator 1 (hydrochloride)

• CAS Number: 2762547-06-6
• UNSPSC Description: CD33 splicing modulator 1 (Compound 1) hydrochloride is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity. CD33 splicing modulator 1 hydrochloride increases exon 2 skipping in cellular mRNA pools. CD33 splicing modulator 1 hydrochloride has the potential for the research of neurodegenerative disease including Alzheimer's disease[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/cd33-splicing-modulator-1-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CN2N=CC(C3=CC=C(C=C3F)C(N([C@@H]4CCCNC4)C5=C(C=CC=N5)C)=O)=C2N=C1.[H]Cl
• Molecular Weight: 480.96
• References & Citations: [1]Chappie TA, et al. Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators. ACS Med Chem Lett. 2022;13(1):55-62.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported