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ML-93

CAT: 0804-HY-176907Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176907Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML-93 is an orally active SAE inhibitor, with an IC50 value of 0.4 μM. ML-93 inhibits the SUMOylation pathway in HCT116 cells. ML-93 shows robust antitumor activity in the HCT116 colorectal carcinoma xenograft model. ML-93 can be used for the study of colorectal cancer[1].
CAS Number
1858275-91-8
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC1=C(C=C(S1)C(C2=CN=CN=C2N[C@@H]3C[C@@H]([C@H](C3)O)COS(N)(=O)=O)=O)[C@H]4C5=CC(Cl)=CC=C5CCO4
Molecular Formula
C25H27ClN4O6S2
Molecular Weight
579.09
References & Citations
[1]Langston SP, et al. Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J Med Chem. 2021 Mar 11;64 (5) :2501-2520.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
GTR19273657-01ML-93
BNUM1047-50CD20 (93-1B3), 1mg/mL
BDE9301ZT10BDE 93 10ug/ml in Iso-octane
BNUB1047-500CD20 (93-1B3), 0.2mg/mL
BDE931ZT1BDE 93 100ug/ml in Iso-octane
BNUM3450-50Alpha Actinin 4 / ACTN4 (93), 1mg/mL
BNCB1047-100CD20 (93-1B3), Biotin conjugate, 0.1mg/mL
BNC471047-100CD20 (93-1B3), CF647 conjugate, 0.1mg/mL
BNC941047-500CD20 (93-1B3), CF594 conjugate, 0.1mg/mL
BNUB3450-500Alpha Actinin 4 / ACTN4 (93), 0.2mg/mL

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