GNE-5152

• Description:

  GNE-5152 is an orthosteric SARM1 base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research[1].

• UNSPSC:

  12352005

• Target:

  Toll-like Receptor (TLR)

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  O=C1N(CCC(C1)C2=CC=C(C(F)=C2)F)C3=CC=C(C4=CC=NC=C4)N=C3

• Molecular Formula:

  C21H17F2N3O

• Molecular Weight:

  365.38

• References & Citations:

  [1]Leahey R, et al. SARM1 orthosteric base exchange inhibitors cause subinhibitory SARM1 activation[J]. bioRxiv, 2024: 2024.08. 06.606489.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3080315-83-6]