GNE-5152

• Target :

  TLR

• Related Pathways :

  Immunology/Inflammation

• Bioactivity :

  GNE-5152 is a straight-chain SARM1 base exchange (BE) inhibitor. Under mild activation conditions, GNE-5152 persistently activates SARM1 at sub-inhibitory concentrations, which synergistically enhances NAD consumption, leading to axonal degeneration and neurodegeneration, and releases neurofilament light chain (NfL) in cortical neurons. GNE-5152 is applicable in neurodegenerative disease research.

• Smiles :

  O=C1N(C=2C=NC(=CC2)C=3C=CN=CC3)CCC(C4=CC=C(F)C(F)=C4)C1

• Molecular Formula :

  C21H17F2N3O

• Molecular Weight :

  365.38

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3080315-83-6