GNE-5152

• Target:

  TLR

• Related Pathways:

  Immunology/Inflammation

• Bioactivity:

  GNE-5152 is a straight-chain SARM1 base exchange (BE) inhibitor. Under mild activation conditions, GNE-5152 persistently activates SARM1 at sub-inhibitory concentrations, which synergistically enhances NAD consumption, leading to axonal degeneration and neurodegeneration, and releases neurofilament light chain (NfL) in cortical neurons. GNE-5152 is applicable in neurodegenerative disease research.

• Smiles:

  O=C1N(C=2C=NC(=CC2)C=3C=CN=CC3)CCC(C4=CC=C(F)C(F)=C4)C1

• Molecular Formula:

  C21H17F2N3O

• Molecular Weight:

  365.38

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3080315-83-6