GNE-5152

CAT: 0931-T212340-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T212340-01Size:10 mg
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CAS Number
3080315-83-6
Target
TLR
Related Pathways
Immunology/Inflammation
Bioactivity
GNE-5152 is a straight-chain SARM1 base exchange (BE) inhibitor. Under mild activation conditions, GNE-5152 persistently activates SARM1 at sub-inhibitory concentrations, which synergistically enhances NAD consumption, leading to axonal degeneration and neurodegeneration, and releases neurofilament light chain (NfL) in cortical neurons. GNE-5152 is applicable in neurodegenerative disease research.
Smiles
O=C1N(C=2C=NC(=CC2)C=3C=CN=CC3)CCC(C4=CC=C(F)C(F)=C4)C1
Molecular Formula
C21H17F2N3O
Molecular Weight
365.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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