GNE-317

• Description:

  GNE-317 is a PI3K/mTOR inhibitor, is able to cross the blood-brain barrier (BBB) .

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  MTOR; PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/GNE-317.html

• Concentration:

  10mM

• Purity:

  98.76

• Solubility:

  DMSO : 20 mg/mL (ultrasonic)

• Smiles:

  NC1=NC=C(C2=NC(N3CCOCC3)=C4C(C(C)=C(C5(OC)COC5)S4)=N2)C=N1

• Molecular Formula:

  C19H22N6O3S

• Molecular Weight:

  414.48

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Salphati L, et al. Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging. Drug Metab Dispos. 2014 Jul;42 (7) :1110-6.|[2]Becker CM, et al. Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma. Neuro Oncol. 2015 Sep;17 (9) :1210-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MTOR; PI3K

• CAS Number:

  [1394076-92-6]