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MrgprX2-IN-1

CAT: 0804-HY-176767Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176767Size:1 Each
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Description
MrgprX2-IN-1 (Compound 2-10) is a selective Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist. MrgprX2-IN-1 blocks IgE-independent immune responses by inhibiting MRGPRX2-mediated mast cell degranulation and release of inflammatory mediators. MrgprX2-IN-1 is promising for research of pseudo-allergic reactions, chronic pruritus, and inflammatory diseases[1].
CAS Number
2792202-91-4
UNSPSC
12352005
Target
Mas-related G-protein-coupled Receptor (MRGPR)
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
O=C(N[C@@H]1CC[C@H](NC2=CC=CC3=NC(C(F)(F)F)=CN23)CC1)C4=C(NN=C5)C5=CC=C4
Molecular Formula
C22H21F3N6O
Molecular Weight
442.44
References & Citations
[1]Marion Lanier, et al. Modulators of mas-related g-protein receptor x2 and related products and methods. WO2022140520A1. 2022-06-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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