MrgprX2-IN-2

• Description :

  MrgprX2-IN-2 (Compound example 12) is a selective Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist. MrgprX2-IN-2 blocks IgE-independent immune responses by inhibiting MRGPRX2-mediated mast cell degranulation and release of inflammatory mediators. MrgprX2-IN-2 is promising for research of pseudo-allergic reactions, chronic pruritus, and inflammatory diseases[1].

• UNSPSC :

  12352005

• Target :

  Mas-related G-protein-coupled Receptor (MRGPR)

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(N[C@H]1CC[C@@H](NC2=CC=CC3=NC(C(F)(F)F)=CN23)CC1)C4=CN(CC(F)(F)F)N=C4Cl

• Molecular Formula :

  C20H19ClF6N6O

• Molecular Weight :

  508.85

• References & Citations :

  [1]Marion Lanier, et al. Modulators of mas-related g-protein receptor x2 and related products and methods. WO2022140520A1. 2022-06-30.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2792205-87-7]