MrgprX2-IN-2

CAT: 0804-HY-176768Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176768Size:1 Each
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Description
MrgprX2-IN-2 (Compound example 12) is a selective Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist. MrgprX2-IN-2 blocks IgE-independent immune responses by inhibiting MRGPRX2-mediated mast cell degranulation and release of inflammatory mediators. MrgprX2-IN-2 is promising for research of pseudo-allergic reactions, chronic pruritus, and inflammatory diseases[1].
CAS Number
[2792205-87-7]
UNSPSC
12352005
Target
Mas-related G-protein-coupled Receptor (MRGPR)
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
O=C(N[C@H]1CC[C@@H](NC2=CC=CC3=NC(C(F)(F)F)=CN23)CC1)C4=CN(CC(F)(F)F)N=C4Cl
Molecular Formula
C20H19ClF6N6O
Molecular Weight
508.85
References & Citations
[1]Marion Lanier, et al. Modulators of mas-related g-protein receptor x2 and related products and methods. WO2022140520A1. 2022-06-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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