HER2-IN-22

• Description:

  HER2-IN-22 is a potent and selective HER2 inhibitor with an IC50 of 215 μM. HER2-IN-22 possesses killing activity against various tumor cells and can induce cell apoptosis. HER2-IN-22 significantly inhibits tumor growth. HER2-IN-22 can be used in the study for tumors such as HER2+ breast cancer[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; EGFR

• Related Pathways:

  Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  N#CC1=C (C2=CC=C (Br) C=C2) N=C (NN=C3C4=CC=C (Br) C=C4) C3=C1C5=CC=C (OC) C (O) =C5

• Molecular Formula:

  C26H16Br2N4O2

• Molecular Weight:

  576.24

• References & Citations:

  [1]Mogheith SM, et al, Design, novel one-pot green synthesis, and biological evaluation of pyrazolopyridine-congeners selectively targeting HER2+ breast cancer. Bioorg Chem. 2025 Jun 12;163:108681.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ErbB2/HER2