HER2-IN-22

• Description :

  HER2-IN-22 is a potent and selective HER2 inhibitor with an IC50 of 215 μM. HER2-IN-22 possesses killing activity against various tumor cells and can induce cell apoptosis. HER2-IN-22 significantly inhibits tumor growth. HER2-IN-22 can be used in the study for tumors such as HER2+ breast cancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; EGFR

• Related Pathways :

  Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  N#CC1=C(C2=CC=C(Br)C=C2)N=C(NN=C3C4=CC=C(Br)C=C4)C3=C1C5=CC=C(OC)C(O)=C5

• Molecular Formula :

  C26H16Br2N4O2

• Molecular Weight :

  576.24

• References & Citations :

  [1]Mogheith SM, et al, Design, novel one-pot green synthesis, and biological evaluation of pyrazolopyridine-congeners selectively targeting HER2+ breast cancer. Bioorg Chem. 2025 Jun 12;163:108681.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ErbB2/HER2