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HER2-IN-22

CAT: 0804-HY-176744Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176744Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HER2-IN-22 is a potent and selective HER2 inhibitor with an IC50 of 215 μM. HER2-IN-22 possesses killing activity against various tumor cells and can induce cell apoptosis. HER2-IN-22 significantly inhibits tumor growth. HER2-IN-22 can be used in the study for tumors such as HER2+ breast cancer[1].
UNSPSC
12352005
Target
Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
N#CC1=C(C2=CC=C(Br)C=C2)N=C(NN=C3C4=CC=C(Br)C=C4)C3=C1C5=CC=C(OC)C(O)=C5
Molecular Formula
C26H16Br2N4O2
Molecular Weight
576.24
References & Citations
[1]Mogheith SM, et al, Design, novel one-pot green synthesis, and biological evaluation of pyrazolopyridine-congeners selectively targeting HER2+ breast cancer. Bioorg Chem. 2025 Jun 12;163:108681.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ErbB2/HER2

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