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PDE3/4-IN-3

CAT: 0804-HY-176524SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176524SSize:1 Each
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Description
PDE3/4-IN-3 (Compound 7) is an orally active dual PDE3/4 inhibitor with IC50 s of 0.17 and ≤50 nM for PDE3A and PDE4B2, respectively. PDE3/4-IN-3 significantly inhibits methacholine-induced bronchoconstriction in guinea pigs. PDE3/4-IN-3 can be used for chronic obstructive pulmonary disease (COPD) and asthma research[1].
CAS Number
2939748-69-1
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(N1C(C2=CC(OC([2H])([2H])[2H])=C(OC)C=C2CC1)=C/3)N(CCNC(N)=O)C3=N\C4=C(C=C(C)C=C4C)C
Molecular Formula
C26H28D3N5O4
Molecular Weight
480.57
References & Citations
[1]Yi L, et al. Tricyclic fused heterocyclic pde3/4 dual inhibitor and use thereof. WO2023109802A1. 2023-06-22.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
PDE3; PDE4

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