Products for Research Use Only
RegisterLogin

PDE5-IN-3

CAT: 0804-HY-131710Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-131710Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PDE5-IN-3 (compound 11j) is a potent PDE5 inhibitor with an IC50 of 1.57 nM. PDE5-IN-3 shows moderate EGFR inhibition with IC50 of 5.827 μM. PDE5-IN-3 significantly inhibits the Wnt/β-catenin pathway (IC50=1286.96 ng/mL) . PDE5-IN-3 induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells. PDE5-IN-3 has strong antitumor activity[1].
CAS Number
2538149-57-2
UNSPSC
12352005
Target
Apoptosis; EGFR; Phosphodiesterase (PDE) ; Wnt
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pde5-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(N(C3=CC=C(Br)C=C3)N=C2)N=C(C4=CC5=CC=CC=C5N=C4OC)N1
Molecular Formula
C21H14BrN5O2
Molecular Weight
448.27
References & Citations
[1]Tarek S Ibrahim, et al. Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy. Bioorg Chem. 2020 Dec;105:104352.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; PDE5

Related Products

CatalogName
HY-124310PDE5-IN-6c
HY-112704PDE5-IN-2
HY-177298PDE5-IN-15
HY-142059-01PDE5-IN-4
HY-176235PDE5-IN-14
HY-149661PDE5-IN-11
HY-W011336-01PDE5-IN-7
HY-128060PDE5-IN-42
HY-153733PDE5-IN-8
HY-155687PDE5-IN-10

Alternative Products

CatalogName
MBS5805361PDE5-IN-3
BA8201-5PDE5-IN-4
T204706-01PDE5-IN-13
T28351-01PDE5-IN-42
T79533-01PDE5-IN-10
T12394-01PDE5-IN-2
MBS5774354PDE5-IN-6c
GTR19219490-01PDE5-IN-11
GTR19185471-01PDE5-IN-5
A4712-500PDE5-IN-7

Popular Products