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ZS34

CAT: 0804-HY-179622Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179622Size:1 Each
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Description
ZS34 is a potent, orally active, and selective MAT2A inhibitor with an IC50 of 13.7 nM, displaying minimal hERG and UGT1A1 liabilities. ZS34 selectively suppresses the growth of methylthioadenosine phosphorylase (MTAP) -deficient cancer cells by inhibiting SAM synthesis, reducing SDMA levels, and inducing DNA damage. ZS34 exhibits antitumor efficacy in a HCT116 MTAP-/- xenograft mouse model. ZS34 can be used for the research of MTAP-deficient cancer[1].
CAS Number
3106086-17-0
UNSPSC
12352005
Target
Methionine Adenosyltransferase (MAT)
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C1N(C2=C(C(NC)=N1)C3=C(C(Cl)=C2)C=CO3)C4=CC=CC=C4C
Molecular Formula
C18H14ClN3O2
Molecular Weight
339.78
References & Citations
[1]Zihan Shi, et al. Furo[2,3-f]quinazolin-7 (6H) -one Derivatives as Potent, Selective, and Orally Bioavailable MAT2A Inhibitors for MTAP-Deficient Cancer Therapy. J. Med. Chem. 2025, 68, 24213-24231
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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