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PROTAC BRD4 Degrader-32

CAT: 0804-HY-176449Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176449Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC BRD4 Degrader-32 (Compound 22) is a BRD4 PROTAC degrader (DC50: 0.20 nM). PROTAC BRD4 Degrader-32 connects the BRD4-binding domain and CRBN-binding domain through a unique carbon-carbon linked linker to form a ternary complex, inducing ubiquitination of BRD4 for proteasomal degradation. PROTAC BRD4 Degrader-32 is promising for research of BRD4-related cancers (such as hematological malignancies). (Pink: GSK1324726A ; Black: linker (HY-176450) ; Blue: Lenalidomide-5-Br (HY-W072954) ).
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC1=CC=C(N[C@@H]2C[C@H](C)N(C(C)=O)C3=C2C=C(C4=CC=C(C(NCCCCC5=CC=C6C(CN(C(CCC(N7)=O)C7=O)C6=O)=C5)=O)C=C4)C=C3)C=C1
Molecular Formula
C42H42ClN5O5
Molecular Weight
732.27
References & Citations
[1]Lovato K, et al. Reductive C (sp2) -C (sp3) Coupling Protocol to Enable Linker Exploration of Cereblon E3-Ligase BRD4 Proteolysis-Targeting Chimeras. J Med Chem. 2025 May 22;68 (10) :10061-10074.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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