DDL-357

• Description :

  DDL-357 is a potent secreted clusterin enhancer. DDL-357 reduces phospho-tau in brain and improves memory in the murine 3xTg-AD model[1].

• CAS Number :

  [3077900-08-1]

• UNSPSC :

  12352005

• Target :

  Tau Protein

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Concentration :

  10mM

• Purity :

  98.31

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=NN=C2[C@H](CC(OC3CC3)=O)N=C(C4=CC=C(Cl)C=C4)C5=C(SC(C)=C5C)N21

• Molecular Formula :

  C22H21ClN4O2S

• Molecular Weight :

  440.95

• References & Citations :

  [1]Cohn W, et al. Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer's disease mice. NPJ Drug Discov. 2025;2 (1) :7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported