SR-3576

• Description:

  SR-3576 is a highly potent and selective JNK3 inhibitor with an IC50 of 7 nM[1].

• UNSPSC:

  12352005

• Target:

  JNK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/sr-3576.html

• Purity:

  99.75

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC1=CC=CC(NC(NC2=CN(C3=CC(C(NC4=CC(OC)=C(OC)C(OC)=C4)=O)=CC=C3)N=C2)=O)=C1

• Molecular Formula:

  C27H27N5O5

• Molecular Weight:

  501.53

• References & Citations:

  [1]Kamenecka T, et al. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 May 8;284 (19) :12853-61.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  JNK3

• CAS Number:

  [1164153-22-3]