Z-3578

CAT: 0804-HY-172458-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-172458-01Size:5 mg
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Description
Z-3578 is a small-molecule antagonist targeting MrgX2 (Mas-related G protein-coupled receptor X2) with significant anti-pseudoallergic activity and a KD value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppressing the release of β-hexosaminidase with IC50 values of 4.90 µM and 6.18 µM, respectively. It also markedly reduces the release of histamine and TNF-α, along with intracellular calcium flux. In a murine pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation and lowers serum histamine levels, indicating potent in vivo anti-allergic effects. Z-3578 holds promise as a lead compound for the treatment of allergic diseases, especially pseudoallergic reactions[1].
CAS Number
[473687-20-6]
UNSPSC
12352005
Target
Mas-related G-protein-coupled Receptor (MRGPR) ; TNF Receptor
Related Pathways
Apoptosis; GPCR/G Protein
Field of Research
Neurological Disease
Purity
98.72
Smiles
O=C(CSC1=NC(C2=CC=CC=C2)=C(N=N1)C3=CC=CC=C3)NC4=C(C=C(C=C4)Cl)Cl
Molecular Formula
C23H16Cl2N4OS
Molecular Weight
467.37
References & Citations
[1]Xia Z, et al. MrgX2-Targeting Ligand Screen for Antipseudoallergic Agents by Immobilized His-Tag-Fused Protein Technology. J Med Chem. 2025 Mar 13;68 (5) :5942-5953.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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