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BI-L-357

CAT: 0804-HY-117784Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117784Size:1 Each
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Description
BI-L-357 is a succinate derived from BI-L-226 that acts as a precursor, enhances oral bioavailability and inhibits 5-lipoxygenase-mediated leukotriene production[1].
CAS Number
149539-02-6
UNSPSC
12352005
Target
Lipoxygenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bi-l-357.html
Smiles
O=C(CCC(O)=O)OC1=C(C=C(C=C1C)/C=C/C2=CC=CS2)C
Molecular Formula
C18H18O4S
Molecular Weight
330.40
References & Citations
[1]A prodrug of a 2,6-disubstituted 4- (2-arylethenyl) phenol is a selective and orally active 5-lipoxygenase inhibitor.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

BI-L 357

prodrug of BL-L 226; a selective & orally active 5-lipoxygenase inhibitor; structure given in first source

CAS Number149539-02-6
PubChem CID6440014
IUPAC Name4-[2,6-dimethyl-4-[(E)-2-thiophen-2-ylethenyl]phenoxy]-4-oxobutanoic acid
Molecular FormulaC18H18O4S
Molecular Weight330.4
XLogP3.8
Topological Polar Surface Area91.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count23
Formal Charge0
Complexity436
SMILES
CC1=CC(=CC(=C1OC(=O)CCC(=O)O)C)/C=C/C2=CC=CS2
InChI
InChI=1S/C18H18O4S/c1-12-10-14(5-6-15-4-3-9-23-15)11-13(2)18(12)22-17(21)8-7-16(19)20/h3-6,9-11H,7-8H2,1-2H3,(H,19,20)/b6-5+
InChIKey
OIDYLVFJAIPWBI-AATRIKPKSA-N
Chemical Structure
2D Structure
2D structure of BI-L 357
CAS: 149539-02-6
CID: 6440014
Formula: C18H18O4S
MW: 330.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight330.4
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass330.09258022
Monoisotopic Mass330.09258022
Topological Polar Surface Area91.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity436
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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