MK-3577

• Description :

  MK-3577 is an orally effective glucagon receptor (GCGR) antagonist that reduces hepatic glucose production and lowers blood glucose levels by blocking glucagon receptors on target organs, primarily the liver. Pharmacokinetic analysis in domestic cats indicates that MK-3577 reaches peak levels 3 to 4 hours after oral administration, with a half-life of approximately 15 hours. MK-3577 can be used in diabetes research[1].

• CAS Number :

  [1019112-29-8]

• UNSPSC :

  12352005

• Target :

  GCGR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/mk-3577.html

• Smiles :

  CCC[C@H](C1=CC=C(C=C1)C(NCCC(O)=O)=O)[C@H](C2=CC=C(C=C2)Cl)C(C3=CC(C)=C4)=CNC3=C4F

• Molecular Formula :

  C30H30ClFN2O3

• Molecular Weight :

  521.02

• References & Citations :

  [1]Mott J, et al. The glucagon-receptor antagonist MK-3577 reduces glucagon-stimulated plasma glucose and insulin concentrations in metabolically healthy overweight cats. Domest Anim Endocrinol. 2024 Oct;89:106874.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2