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HKI-357 dimaleate

CAT: 0931-T68360-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68360-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
915942-25-5
Target
Others, EGFR
Related Pathways
Others, JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
Smiles
OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
Molecular Formula
C39H37ClFN5O11
Molecular Weight
806.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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