HKI-357 dimaleate

• Target :

  Others|||EGFR

• Related Pathways :

  Others|||JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors

• Bioactivity :

  HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.

• Smiles :

  OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C

• Molecular Formula :

  C39H37ClFN5O11

• Molecular Weight :

  806.2

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  915942-25-5