Thalidomide-4-PEG4-OTs

• Description:

  Thalidomide-4-OH-PEG4-OTs is an E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based CRBN ligand (HY-103596) and 4-unit PEG linker (HY-176182) . Thalidomide-4-OH-PEG4-OTs can be used for synthesis of PROTAC STING degrader-4 (HY-176180) [1].

• UNSPSC:

  12352005

• Target:

  E3 Ligase Ligand-Linker Conjugates

• Related Pathways:

  PROTAC

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(N1C2CCC(NC2=O)=O)C3=C(OCCOCCOCCOCCOS(C4=CC=C(C=C4)C)(=O)=O)C=CC=C3C1=O

• Molecular Formula:

  C28H32N2O11S

• Molecular Weight:

  604.63

• References & Citations:

  [1]An Y, et al. Discovery of indole derivatives as STING degraders. Eur J Med Chem. 2025 May 12; 294:117747.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3023389-80-9]