Thalidomide-PEG1-OTs

• Description:

  Thalidomide-PEG1-OTs (Compound 5) is a ligand for E3 ligase, used for the synthesis of YD54 (HY-168221) [1].

• UNSPSC:

  12352005

• Target:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-peg1-ots.html

• Smiles:

  O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC=C3OCCOS(C4=CC=C(C)C=C4)(=O)=O

• Molecular Formula:

  C22H20N2O8S

• Molecular Weight:

  472.47

• References & Citations:

  [1]Kotagiri S, et al. Discovery of Novel, Potent and Orally Bioavailable SMARCA2 PROTACs with Synergistic Anti-tumor Activity in Combination with KRAS G12C Inhibitors. bioRxiv [Preprint]. 2024 Aug 26:2024.08.23.608456.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2850354-04-8