Thalidomide-PEG4-COOH

CAT: 0804-HY-138774-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-138774-01Size:25 mg
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Description
Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
CAS Number
[2828438-28-2]
UNSPSC
12352005
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-peg4-cooh.html
Purity
95.36
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC(OCCOCCOCCOCCC(O)=O)=CC=C31)=O
Molecular Formula
C22H26N2O10
Molecular Weight
478.45
References & Citations
[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-986.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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