Thalidomide-PEG4-Propargyl

• Description :

  Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Hazard Statement :

  H360

• Target :

  Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/thalidomide-peg4-propargyl.html

• Purity :

  98.0

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCC#C)=O

• Molecular Formula :

  C24H28N2O9

• Molecular Weight :

  488.49

• Precautions :

  P280-P405-P501

• References & Citations :

  [1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-998.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon

• CAS Number :

  [2098799-77-8]