BTK-IN-44

CAT: 0804-HY-176172Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176172Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BTK-IN-44 (Compound 10) is a potent noncovalent inhibitor of Bruton’s tyrosine kinase (BTK) with an IC50 value of 24.7 nM. BTK-IN-44 interferes with signaling pathways of B cell malignancies, showing antitumor effects in lymphoma cells. BTK-IN-44 is promising for research of B cell malignancies (such as lymphoma) [1].
UNSPSC
12352005
Target
Btk
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC1=C(NC(C2=CC3=C(C=CC=C3)N2)=O)C=CC=C1C4=CC=C5C(NC6=CC(C(O)(C)C)=CC=C6N54)=O
Molecular Formula
C30H26N4O3
Molecular Weight
490.55
References & Citations
[1]Tian C, et al. Structure-based design of novel pyrrolo[1,2-a]quinoxalin-4 (5H) -one derivatives as potent noncovalent Bruton's tyrosine kinase (BTK) inhibitors. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130285.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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