BTK-IN-9

• Description :

  BTK-IN-9 is a reversible BTK inhibitors with potent antiproliferative activity in mantle cell lymphoma. BTK-IN-9 specifically disturbs mitochondrial membrane potential and increases reactive oxygen species level in Z138 cells. BTK-IN-9 also induces cell apoptosis in Z138 cells[1].

• CAS Number :

  [2361192-21-2]

• UNSPSC :

  12352005

• Target :

  Apoptosis; Btk

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Protein Tyrosine Kinase/RTK

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/btk-in-9.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=CC=C([N+]([O-])=O)C=C1)CN2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C5=C(N)N=CN=C52

• Molecular Formula :

  C25H19N7O4

• Molecular Weight :

  481.46

• References & Citations :

  [1]Ran F, et al. Design and synthesis of novel pyrazolopyrimidine-based derivatives as reversible BTK inhibitors with potent antiproliferative activity in mantle cell lymphoma. Med Chem Res, 2022, 31, 594-604.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported