BTK-IN-9

CAT: 0804-HY-115944Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-115944Size:1 Each
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Description
BTK-IN-9 is a reversible BTK inhibitors with potent antiproliferative activity in mantle cell lymphoma. BTK-IN-9 specifically disturbs mitochondrial membrane potential and increases reactive oxygen species level in Z138 cells. BTK-IN-9 also induces cell apoptosis in Z138 cells[1].
CAS Number
[2361192-21-2]
UNSPSC
12352005
Target
Apoptosis; Btk
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/btk-in-9.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C([N+]([O-])=O)C=C1)CN2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C5=C(N)N=CN=C52
Molecular Formula
C25H19N7O4
Molecular Weight
481.46
References & Citations
[1]Ran F, et al. Design and synthesis of novel pyrazolopyrimidine-based derivatives as reversible BTK inhibitors with potent antiproliferative activity in mantle cell lymphoma. Med Chem Res, 2022, 31, 594-604.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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