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PD-M6

CAT: 0804-HY-176166Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176166Size:1 Each
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Description
PD-M6 is an mTOR PROTAC degrader (DC50: 4.8 μM). PD-M6 promotes the ubiquitination and degradation of mTOR. PD-M6 inhibits the proliferation of HeLa, MCF-7, and HepG2 cancer cell lines (IC50 values of 11.3, 2.58, and 3.23 μM, respectively) and induces autophagy. PD-M6 specifically induces the degradation of LAMTOR1, a key protein in the mTOR signaling pathway. (Pink: target protein mTOR ligand ; target protein mTOR ligand activity control (HY-W150930) ; black: linker (HY-W008296) ; blue: E3 ligase CRBN ligand (HY-41547) ; target protein ligand activity control + linker (HY-176167) ).
CAS Number
3058330-82-5
UNSPSC
12352005
Target
MTOR; PROTACs
Related Pathways
PI3K/Akt/mTOR; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC(NCCCCCCNC4=NC(N5CCOCC5)=NC(N6CCOCC6)=N4)=C13)=O
Molecular Formula
C30H39N9O6
Molecular Weight
621.69
References & Citations
[1]Zhu L, et al. Reversing an agonist into an inhibitor: Development of mTOR degraders. Eur J Med Chem. 2025 May 17;294:117774.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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