PD-M6

CAT: 0931-T207406-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T207406-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3058330-82-5

Target

MTOR, PROTACs

Related Pathways

PI3K/Akt/mTOR signaling, PROTAC

Bioactivity

PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.

Smiles

O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCCCNC=4N=C(N=C(N4)N5CCOCC5)N6CCOCC6)C3C2=O)CC1

Molecular Formula

C30H39N9O6

Molecular Weight

621.69

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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