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AChE/BChE-IN-30

CAT: 0804-HY-175973Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175973Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/BChE-IN-30 (Compound 3g) is a Cholinesterase dual-target competitive inhibitor. AChE/BChE-IN-30 can inhibit AChE and BChE with IC50 values of 0.338 and 2.087 μM and Ki values of 0.045 and 0.789 μM. AChE/BChE-IN-30 has no obvious toxicity to human umbilical vein endothelial cells (HUVEC) and does not inhibit the CYP2C19 enzyme. AChE/BChE-IN-30 can be used for the research of neurological disease, such as Alzheimer's disease[1].
UNSPSC
12352005
Target
Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
N#CC1=CC=C(C2=CSC(N3N=C(C4=CC=C(OC)C(OC)=C4)CC3C5=CC=C(C)S5)=N2)C=C1
Molecular Formula
C26H22N4O2S2
Molecular Weight
486.61
References & Citations
[1]Kaya B, et al. Design, Synthesis, and Molecular Docking Studies of Novel Pyrazoline-Thiazoles as Cholinesterase Dual-Target Inhibitors for the Treatment of Alzheimer's Disease. ACS Omega. 2025 Aug 22;10 (34) :38427-38439.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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