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PROTAC SMARCA2 degrader-34

CAT: 0804-HY-175867Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175867Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC SMARCA2 degrader-34 (compound 52) is a selective SMARCA2 PROTAC degrader (DC50 in HeLa cell: SMARCA2, > 1 μM for SMARCA4). PROTAC SMARCA2 degrader-34 can be used for study of cancer. (Pink: SMARCA2 ligand ; Blue: E3 ligand (HY-168055) ; Black: linker).
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
FC([C@]12N(C[C@H](N3C4=C(CN(CC5CCN(C6=CC=C(CN([C@@H]7C(NC(CC7)=O)=O)C8=O)C8=C6)CC5)C(C)C4)C=N3)C2)C9=CC(C%10=C(C(F)=CC=C%10)O)=NN=C9NC1)F
Molecular Formula
C42H45F3N10O4
Molecular Weight
810.87
References & Citations
[1]Artem SHVARTSBART, et al. Brm targeting compounds and associated methods of use. WO2025101738A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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