MBL-IN-6

• Description:

  MBL-IN-6 (Compound 6d) is a Metallo-β-lactamase (MBL) inhibitor with Kis of 2.6 and 0.08 μM for NDM-1 and VIM-2, respectively. MBL-IN-6 has a synergistic activities with Imipenem (HY-B1369A) on MBL-producing clinical isolates (such as E. coli SI-M001, K. pneumonia T2301 and S. marcescens SI-1591) with MICs of 2-64 μg/mL. MBL-IN-6 does not have off-target effects without ACE-1 inhibition activity. MBL-IN-6 can be used for antimicrobial resistance research[1].

• UNSPSC:

  12352005

• Target:

  Bacterial; Beta-lactamase

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  O=C (N) [C@@H]1N (C2=CC=CC=C2C1 (CC) CC) C ([C@@H] (CS) C) =O

• Molecular Formula:

  C17H24N2O2S

• Molecular Weight:

  320.45

• References & Citations:

  [1]Alfano AI, et al. Sustainable Joullié-Ugi and Continuous Flow Implementation Led to Novel Captopril-Inspired Broad-Spectrum Metallo-β-Lactamase Inhibitors. J Med Chem. 2025 Aug 28;68 (16) :17236-17257.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported