MBL-IN-5

• Description:

  MBL-IN-5 is a metallo-β-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC50s of 0.05 nM, 14 nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems’ effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic[1].

• UNSPSC:

  12352005

• Target:

  Bacterial; Beta-lactamase

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  O=C (C1=C (C2=C (OC) C=CC (Cl) =C2) C3=C (C4=C (CC3) C=CC=C4) N1) O

• Molecular Formula:

  C20H16ClNO3

• Molecular Weight:

  353.80

• References & Citations:

  [1]Dhiman P, et al. Discovery of Conformationally Constrained Dihydro Benzo-Indole Derivatives as Metallo-β-Lactamase Inhibitors to Tackle Multidrug-Resistant Bacterial Infections. J Med Chem. 2025 Apr 10;68 (7) :7062-7081.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Metallo-β-lactamase (MBL)

• CAS Number:

  2876921-34-3