MBL-IN-5

• Target:

  Beta-lactamase|||Antibacterial

• Related Pathways:

  Microbiology/Virology

• Bioactivity:

  MBL-IN-5 is an inhibitor of metallo-?-lactamase (MBL) . It effectively suppresses three clinically significant B1 subfamily MBLs: NDM-1, VIM-1, and IMP-1 with IC50 values of 0.05 nM, 14 nM, and 21 nM respectively. MBL-IN-5 notably enhances the efficacy of carbapenem antibiotics against MBL-producing clinical strains and, when combined with IPM antibiotics, significantly reduces bacterial load in a thigh infection model.

• Smiles:

  O=C(O)C=1NC=2C=3C=CC=CC3CCC2C1C=4C=C(Cl)C=CC4OC

• Molecular Formula:

  C20H16ClNO3

• Molecular Weight:

  353.8

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2876921-34-3