EYE-002

CAT: 0804-HY-175663Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175663Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EYE-002 is a RPE65 inhibitor with an IC50 of 69 nM. EYE-002 promotes recovery of scotopic ERG a-/b-wave amplitudes. EYE-002 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs) . EYE-002 exerts protective effects against photic retinal damage in mice. EYE-002 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) [1].
UNSPSC
12352100
Target
RPE65
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=CO.CCC(CC)C(OC1=CC=CC(C(O)CCN)=C1)=O
Molecular Formula
C16H25NO5
Molecular Weight
311.37
References & Citations
[1]Bassetto M, et al. Rationally Designed, Short-Acting RPE65 Inhibitors for Visual Cycle-Associated Retinopathies. J Med Chem. 2025 Aug 28;68 (16) :17638-17652.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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