ICP-103

• Description:

  ICP-103 (Compound 3K) is a highly selective protein kinase C (PKC) inhibitor with an IC50 of 30 nM. ICP-103 is promising for research of cancers[1][2].

• UNSPSC:

  12352005

• Target:

  PKC

• Related Pathways:

  Epigenetics; TGF-beta/Smad

• Field of Research:

  Cancer

• Smiles:

  N#CCCN(C1=C2C(C(NC3=O)=O)=C3C4=C1N(C)C5=C4C=CC=C5)C6=C2C=CC=C6

• Molecular Formula:

  C24H16N4O2

• Molecular Weight:

  392.41

• References & Citations:

  [1]Kleinschroth J, Hartenstein J, Rudolph C, et al. Novel indolocarbazole protein kinase C inhibitors with improved biochemical and physicochemical properties[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5 (1) : 55-60.|[2]Roy S, Eastman A, Gribble G W. Synthesis of 7‐keto‐Gö6976 (ICP‐103) [J]. Synthetic communications, 2005, 35 (4) : 595-601.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [153997-72-9]