NL-103

CAT: 0804-HY-12487Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-12487Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
NL-103 is an inhibitor of histone deacetylases (HDACs) and Hedgehog, with the IC50 values ​​of 21.3 nM, 57 nM, 74 nM, and 680 nM for HDAC1, HDAC2, HDAC3, and HDAC6, respectively. NL-103 can downregulate the expression of Gli2. NL-103 can be used in anti-cancer research[1].
CAS Number
[1788896-33-2]
UNSPSC
12352005
Target
Gli; HDAC; Hedgehog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nl-103.html
Smiles
O=C(C1=CN=C(NCCCCCCC(NO)=O)C=C1)NC2=CC=C(C(NC(C3=CC(Cl)=CC=C3)=O)=C2)Cl
Molecular Formula
C26H27Cl2N5O4
Molecular Weight
544.43
References & Citations
[1]Zhao J, et al. NL-103, a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. Pharmacol Res Perspect. 2014 Jun;2 (3) :e00043.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6

Related Products

CatalogName
HY-135231-01NL-1
HY-P11319RAP-103
HY-163354EGFR-IN-103
HY-173064DS-103
HY-13758TAS-103
HY-134778BMS-103
HY-161979HSD17B13-IN-103
HY-179508α-Glucosidase-IN-103
HY-P6053KK-103
HY-P991217EU-103

Alternative Products

CatalogName
MBS5812737NL-103
ASF130-22-NLNL
MBS3611560-01NL-1
MBS3612496-01CB-103
WGC308049-5mgPI-103
MBS5757113ICP 103
P215070PBB 103
B1841-5TAS-103

Popular Products