NL-103

• Description:

  NL-103 is an inhibitor of histone deacetylases (HDACs) and Hedgehog, with the IC50 values ​​of 21.3 nM, 57 nM, 74 nM, and 680 nM for HDAC1, HDAC2, HDAC3, and HDAC6, respectively. NL-103 can downregulate the expression of Gli2. NL-103 can be used in anti-cancer research[1].

• UNSPSC:

  12352005

• Target:

  Gli; HDAC; Hedgehog

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nl-103.html

• Smiles:

  O=C(C1=CN=C(NCCCCCCC(NO)=O)C=C1)NC2=CC=C(C(NC(C3=CC(Cl)=CC=C3)=O)=C2)Cl

• Molecular Formula:

  C26H27Cl2N5O4

• Molecular Weight:

  544.43

• References & Citations:

  [1]Zhao J, et al. NL-103, a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. Pharmacol Res Perspect. 2014 Jun;2 (3) :e00043.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC1; HDAC2; HDAC3; HDAC6

• CAS Number:

  [1788896-33-2]