YZ-35

• Description:

  YZ-35 is a STAT3 inhibitor, with a Ki value of 0.38 μM. YZ-35 binds directly to STAT3 with high affinity, exhibiting a dissociation constant (Kd) of 190 nM. YZ-35 directly attenuates the dual phosphorylation of STAT3 (Tyr705 and Ser727) . YZ-35 suppresses colony formation, cellular migration, and induces apoptosis in breast cancer cell lines (BCSC) . YZ-35 selectively suppresses BCSC self-renewal. YZ-35 inhibits tumor growth in the BCSC xenograft models. YZ-35 can be used for the study of breast cancer[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; STAT

• Related Pathways:

  Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  O=C(CC1=CC2=C(C=CC=C2)N1)NCC(C3=O)=C(C(C4=C3C=CC=C4OC)=O)SC5=CC=C(C=C5)OC

• Molecular Formula:

  C29H24N2O5S

• Molecular Weight:

  512.58

• References & Citations:

  [1]Zhang Z, et al. Discovery of Juglone Derivatives as Novel STAT3 Inhibitors with Potent Suppression of Cancer Cell Stemness against Breast Cancer. J Med Chem. 2025 Jul 24;68 (14) :15085-15109.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported