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YZ-35

CAT: 0804-HY-175253Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175253Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YZ-35 is a STAT3 inhibitor, with a Ki value of 0.38 μM. YZ-35 binds directly to STAT3 with high affinity, exhibiting a dissociation constant (Kd) of 190 nM. YZ-35 directly attenuates the dual phosphorylation of STAT3 (Tyr705 and Ser727) . YZ-35 suppresses colony formation, cellular migration, and induces apoptosis in breast cancer cell lines (BCSC) . YZ-35 selectively suppresses BCSC self-renewal. YZ-35 inhibits tumor growth in the BCSC xenograft models. YZ-35 can be used for the study of breast cancer[1].
UNSPSC
12352005
Target
Apoptosis; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(CC1=CC2=C(C=CC=C2)N1)NCC(C3=O)=C(C(C4=C3C=CC=C4OC)=O)SC5=CC=C(C=C5)OC
Molecular Formula
C29H24N2O5S
Molecular Weight
512.58
References & Citations
[1]Zhang Z, et al. Discovery of Juglone Derivatives as Novel STAT3 Inhibitors with Potent Suppression of Cancer Cell Stemness against Breast Cancer. J Med Chem. 2025 Jul 24;68 (14) :15085-15109.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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