AS-35

CAT: 0804-HY-101946-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101946-01Size:1 mg
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Description
AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.
CAS Number
[108427-72-1]
UNSPSC
12352005
Target
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/AS-35.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C2=NN=NN2)=CN=C3N1C=CC=C3COC4=CC=C(C(C)=O)C(O)=C4CCC
Molecular Formula
C21H20N6O4
Molecular Weight
420.42
References & Citations
[1]Kasai H, et al. Peptide leukotriene antagonistic activity of AS-35, a new antiallergic drug. Jpn J Pharmacol. 1992 Apr;58 (4) :347-55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
LTC4/CysLT2; LTD4/CysLT1; LTE4

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