AS-35

• Description :

  AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.

• UNSPSC :

  12352005

• Target :

  Leukotriene Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/AS-35.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C(C2=NN=NN2)=CN=C3N1C=CC=C3COC4=CC=C(C(C)=O)C(O)=C4CCC

• Molecular Formula :

  C21H20N6O4

• Molecular Weight :

  420.42

• References & Citations :

  [1]Kasai H, et al. Peptide leukotriene antagonistic activity of AS-35, a new antiallergic drug. Jpn J Pharmacol. 1992 Apr;58 (4) :347-55.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  LTC4/CysLT2; LTD4/CysLT1; LTE4

• CAS Number :

  [108427-72-1]