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YZ-35

CAT: 0013-GTR19263743-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263743-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YZ-35 is a STAT3 inhibitor with a Ki value of 0.38 μM. It binds directly to STAT3 with high affinity, having a dissociation constant (Kd) of 190 nM. YZ-35 effectively inhibits the dual phosphorylation of STAT3 at Tyr705 and Ser727 sites. It also suppresses colony formation, cell migration, and induces apoptosis in breast cancer cell lines. Additionally, YZ-35 selectively inhibits the self-renewal capability of breast cancer stem cells (BCSC) and reduces tumor growth in breast cancer stem cell xenograft models. YZ-35 is applicable for breast cancer research.
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Storage Conditions
-20°C
Notes
For research use only.

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